ABSTRACT
Background: Hypertensive disorders of pregnancy pose several problems to both mother and newborn. Complications in new-born like intrauterine death (IUD), intrauterine growth retardation (IUGR), perinatal asphyxia, neonatal sepsis and bleeding disorders are associated with toxemia of pregnancy. To decrease the perinatal morbidity and mortality, babies of hypertensive mothers should be carefully monitored and managed. Aim of this study was to establish the changes in total platelet count in umbilical cord blood.Methods: This is a hospital based prospective observational study which included the babies born to mothers having hypertensive disorders of pregnancy, total cases accounting about 158. Detailed clinical history taken including details of labour and clinical examination done.' In all the subjects, 2 ml of umbilical cord blood anticoagulated with EDTA was collected and haematological tests for total platelet count (TPC) count was done.Results: This study shows that the incidence of neonatal thrombocytopenia is 43.67%. The incidence of sepsis among thrombocytopenia group accounts for about 60% in gestational hypertension, 64.2% in pre-eclampsia and 50% in eclampsia group.Conclusions: With respectively, these findings it can be concluded that the incidence of Neonatal Thrombocytopenia is significantly higher in babies born to HDP mothers and it can be taken as a marker to evaluate Sepsis in such a situation in resource limited setting. As less number of studies is available in this area of interest, this study supports the cause.
ABSTRACT
Background: Syndrome of inappropriate antidiuretic hormone is an important metabolic complication of perinatal asphyxia. This study aims to study the occurrence of syndrome of inappropriate antidiuretic hormone in different grades of perinatal asphyxia and to find out the correlation of syndrome of inappropriate antidiuretic hormone to gestational age and birth weight in birth asphyxiated babies.Methods: It was a hospital-based cohort study. 50 neonates with different grades of asphyxia were enrolled in the study and 50 controls were taken. Syndrome of inappropriate antidiuretic hormone was diagnosed based on calculated plasma osmolality, serum and urine sodium, urine specific gravity and analyzed with different grades of birth asphyxia and birthweight and gestation age.Results: The occurrence of SIADH in birth asphyxiated babies was 26% and none of the babies in control group developed SIADH. The occurrence was more in the severely asphyxiated babies (53.8%), followed by moderate (30.8%) and then mildly asphyxiated babies (15.4%). Hyponatremia was seen in 26% of birth asphyxiated babies and can be used as a marker of SIADH. In relation to gestation age and birth weight there was no statistically significant correlation between SIADH and different grades of asphyxia. Mortality was high among the neonates who developed SIADH.Conclusions: The occurrence of SIADH was 26% in asphyxiated neonates and high in severe asphyxia and gestation age and birth weight beard no significant co relation.
ABSTRACT
Background: Kangaroo Mother Care (KMC)' is an alternative to conventional neonatal care for low birth weight (LBW)' babies' in low resource settings, this study is to evaluate the correlation between the duration of KMC given and average weight gain per day in low birth weight babiesMethod: It is an observational study, 106 low birth weight babies who were less than 1.8 kg, hemodynamically stable, accepting either direct breast feed or gavage feed were included in the study, duration of KMC given per day and weight was recorded daily until discharge. Babies were monitored for complications, if any' babies were withdrawn from the study , necessary intervention was done. Average weight gain per day in these babies was estimated and correlated with the average duration of KMC.Results: Out of 120 eligible children 106 were selected for study of which 57 were male and 49 were female, 42 were 'less than 1.2 kg, 37 were between 1.21 kg to 1.5 kg and 27 were between 1.51 kg to 1.8 kg, there was statistically significant moderate correlation with Pearson r=0.6281 with p value <0.00001 and mean average weight gain was 5.27 in less than '6 hr' to 8 hr, 9.08 in 8 hr to 10 hr, 11.87 in greater than 10 hrs of KMCConclusion: The weight gain was found to increase with duration of KMC practice. hence authors recommend to increase the duration of KMC per day for the good average weight gain per day.